A robust model-free approach for rare variants association studies incorporating gene-gene and gene-environmental interactions.

ABSTRACT: Recently more and more evidence suggest that rare variants with much lower minor allele frequencies play significant roles in disease etiology. Advances in next-generation sequencing technologies will lead to many more rare variants association studies. Several statistical methods have been proposed to assess the effect of rare variants by aggregating information from multiple loci across a genetic region and testing the association between the phenotype and aggregated genotype. One limitation of existing methods is that they only look into the marginal effects of rare variants but do not systematically take into account effects due to interactions among rare variants and between rare variants and environmental factors. In this article, we propose the summation of partition approach (SPA),

SUBMITTER: Fan R 

PROVIDER: S-EPMC3866272 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature