Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery.

ABSTRACT:

Background

Cardiac surgery is frequently complicated by an acute vascular lung injury and this may be mediated, at least in part, by the (soluble) receptor for advanced glycation end products (sRAGE).

Methods

In two university hospital intensive care units, circulating sRAGE was measured together with the 68Gallium-transferrin pulmonary leak index (PLI), a measure of pulmonary vascular permeabiliy, in 60 consecutive cardiac surgery patients stratified by the amount of blood transfusion, within 3 hours of admission to the intensive care.

Results

Cardiac surgery resulted in elevated plasma sRAGE levels compared to baseline (315 ± 181 vs 110 ± 55 pg/ml, P = 0.001). In 37 patients the PLI was elevated 50% above normal. The PLI correlated with sRAGE (r2 = 0.11, P = 0.018).

SUBMITTER: Tuinman PR 

PROVIDER: S-EPMC3866278 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature