Functional roles of the amino terminal domain in determining biophysical properties of Cx50 gap junction channels.

ABSTRACT: Communication through gap junction channels is essential for synchronized and coordinated cellular activities. The gap junction channel pore size, its switch control for opening/closing, and the modulations by chemicals can be different depending on the connexin subtypes that compose the channel. Recent structural and functional studies provide compelling evidence that the amino terminal (NT) domains of several connexins line the pore of gap junction channels and play an important role in single channel conductance (γ j ) and transjunctional voltage-dependent gating (V j -gating). This article reviews recent studies conducted on a series of mutations/chimeras in the NT domain of connexin50 (Cx50). Functional examination of the gap junction channels formed by these mutants/chimeras shows th

SUBMITTER: Xin L 

PROVIDER: S-EPMC3866381 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature