Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha DL1.

ABSTRACT:

Background

Hansenula polymorpha DL1 is a methylotrophic yeast, widely used in fundamental studies of methanol metabolism, peroxisome biogenesis and function, and also as a microbial cell factory for production of recombinant proteins and metabolic engineering towards the goal of high temperature ethanol production.

Results

We have sequenced the 9 Mbp H. polymorpha DL1 genome and performed whole-genome analysis for the H. polymorpha transcriptome obtained from both methanol- and glucose-grown cells. RNA-seq analysis revealed the complex and dynamic character of the H. polymorpha transcriptome under the two studied conditions, identified abundant and highly unregulated expression of 40% of the genome in methanol grown cells, and revealed alternative splicing events. We have id

SUBMITTER: Ravin NV 

PROVIDER: S-EPMC3866509 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature