Telling metabolic stories to explore metabolomics data: a case study on the yeast response to cadmium exposure.

ABSTRACT:

Motivation

The increasing availability of metabolomics data enables to better understand the metabolic processes involved in the immediate response of an organism to environmental changes and stress. The data usually come in the form of a list of metabolites whose concentrations significantly changed under some conditions, and are thus not easy to interpret without being able to precisely visualize how such metabolites are interconnected.

Results

We present a method that enables to organize the data from any metabolomics experiment into metabolic stories. Each story corresponds to a possible scenario explaining the flow of matter between the metabolites of interest. These scenarios may then be ranked in different ways depending on which interpretation one wishes to emphasize

SUBMITTER: Milreu PV 

PROVIDER: S-EPMC3866556 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature