EXPANDS: expanding ploidy and allele frequency on nested subpopulations.

ABSTRACT:

Motivation

Several cancer types consist of multiple genetically and phenotypically distinct subpopulations. The underlying mechanism for this intra-tumoral heterogeneity can be explained by the clonal evolution model, whereby growth advantageous mutations cause the expansion of cancer cell subclones. The recurrent phenotype of many cancers may be a consequence of these coexisting subpopulations responding unequally to therapies. Methods to computationally infer tumor evolution and subpopulation diversity are emerging and they hold the promise to improve the understanding of genetic and molecular determinants of recurrence.

Results

To address cellular subpopulation dynamics within human tumors, we developed a bioinformatic method, EXPANDS. It estimates the proportion of cells

SUBMITTER: Andor N 

PROVIDER: S-EPMC3866558 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature