The role of Dichaete in transcriptional regulation during Drosophila embryonic development.

ABSTRACT:

Background

Group B Sox domain transcription factors play conserved roles in the specification and development of the nervous system in higher metazoans. However, we know comparatively little about how these transcription factors regulate gene expression, and the analysis of Sox gene function in vertebrates is confounded by functional compensation between three closely related family members. In Drosophila, only two group B Sox genes, Dichaete and SoxN, have been shown to function during embryonic CNS development, providing a simpler system for understanding the functions of this important class of regulators.

Results

Using a combination of transcriptional profiling and genome-wide binding analysis we conservatively identify over 1000 high confidence direct Dichaete target ge

SUBMITTER: Aleksic J 

PROVIDER: S-EPMC3866562 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature