Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer.

ABSTRACT:

Background/aim

Geographic gradients in breast cancer incidence and mortality suggest that vitamin D may reduce risk. The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. We investigated six polymorphisms in CYP24A1 and two in the VDR gene in association with breast cancer risk.

Materials and methods

We conducted a case-control study within the nationwide U.S. Radiologic Technologists cohort, including 845 controls and 484 incident breast cancer cases. Associations of polymorphic variants and ecologic and personal measures of sun exposure with breast cancer risk were assessed using unconditional logistic regression.

Results

Two polymorphisms in CYP24A1 wer

SUBMITTER: Fuhrman BJ 

PROVIDER: S-EPMC3866631 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature