Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs.

ABSTRACT: Transplantation of organs between genetically different individuals of the same species causes a T cell-mediated immune response that, if left unchecked, results in rejection and graft destruction. The potency of the alloimmune response is determined by the antigenic disparity that usually exists between donors and recipients and by intragraft expression of proinflammatory cytokines in the early period after transplantation. Studies in animal models have identified many molecules that, when targeted, inhibit T-cell activation. In addition, some of these studies have shown that certain immunologic interventions induce transplantation tolerance, a state in which the allograft is specifically accepted without the need for chronic immunosuppression. Tolerance is an important aspect of liver tr

SUBMITTER: Sanchez-Fueyo A 

PROVIDER: S-EPMC3866688 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature