Pharmacogenetics in clinical pediatrics: challenges and strategies.

ABSTRACT: The use of genetic information to guide medication decisions holds great promise to improve therapeutic outcomes through increased efficacy and reduced adverse events. As in many areas of medicine, pediatric research and clinical implementation in pharmacogenetics lag behind corresponding adult discovery and clinical applications. In adults, genotype-guided clinical decision support for medications such as clopidogrel, warfarin and simvastatin are in use in some medical centers. However, research conducted in pediatric populations demonstrates that the models and practices developed in adults may be inaccurate in children, and some applications lack any pediatric research to guide clinical decisions. To account for additional factors introduced by developmental considerations in pediatric

SUBMITTER: Van Driest SL 

PROVIDER: S-EPMC3866691 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature