Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.

ABSTRACT:

Objective

To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul, Afghanistan.

Methods

This double-blind placebo-controlled trial randomized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vitamin D3 (cholecalciferol 100000 IU) or placebo in inner city Kabul. Data on diarrheal episodes (≥ 3 loose/liquid stools in 24 hours) was gathered through active and passive surveillance over 18 months of follow-up. Time to first diarrheal illness was analyzed by using Kaplan-Meier plots. Incidence rates and hazard ratios (HRs) were calculated by using recurrent event Poisson regression models.

Results

No significant difference existed in survival time to f

SUBMITTER: Aluisio AR 

PROVIDER: S-EPMC3866796 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature