Functional characterization of two members of histidine phosphatase superfamily in Mycobacterium tuberculosis.

ABSTRACT:

Background

Functional characterization of genes in important pathogenic bacteria such as Mycobacterium tuberculosis is imperative. Rv2135c, which was originally annotated as conserved hypothetical, has been found to be associated with membrane protein fractions of H37Rv strain. The gene appears to contain histidine phosphatase motif common to both cofactor-dependent phosphoglycerate mutases and acid phosphatases in the histidine phosphatase superfamily. The functions of many of the members of this superfamily are annotated based only on similarity to known proteins using automatic annotation systems, which can be erroneous. In addition, the motif at the N-terminal of Rv2135c is 'RHA' unlike 'RHG' found in most members of histidine phosphatase superfamily. These necessitate the need

SUBMITTER: Coker OO 

PROVIDER: S-EPMC3866925 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature