Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep.

ABSTRACT:

Background

Sheep caseous lymphadenitis (CLA), caused by Corynebacterium pseudotuberculosis (Cp), is associated with direct economic losses and presents significant zoonotic potential. Despite the importance of the disease, a satisfactory vaccine model has not been developed. Thus, this study aimed to investigate the association between haptoglobin (Hp) and IgM levels and the clinical progression of CLA in primarily infected sheep and in sheep immunized with Cp- secreted antigens adjuvanted with Quillaja saponaria saponins. These animals were kept with CLA-positive sheep to simulate natural exposure that occurs in field conditions. During the experiment, the Hp and IgM levels were monitored for 21 days, and the development of internal CLA lesions was investigated through necropsies

SUBMITTER: Bastos BL 

PROVIDER: S-EPMC3866939 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature