Increased prefrontal cortex activity during negative emotion regulation as a predictor of depression symptom severity trajectory over 6 months.

ABSTRACT:

Importance

Emotion regulation is critically disrupted in depression, and the use of paradigms that tap into these processes may uncover essential changes in neurobiology during treatment. In addition, because neuroimaging outcome studies of depression commonly use only baseline and end-point data-which are more prone to week-to-week noise in symptomatology-we sought to use all data points over the course of a 6-month trial.

Objective

To examine changes in neurobiology resulting from successful treatment.

Design, setting, and participants

Double-blind trial examining changes in the neural circuits involved in emotion regulation resulting from 1 of 2 antidepressant treatments during a 6-month trial. Twenty-one patients with major depressive disorder and without other Ax

SUBMITTER: Heller AS 

PROVIDER: S-EPMC3866958 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature