Maintenance treatment after induction therapy in non-small cell lung cancer: latest evidence and clinical implications.

ABSTRACT: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the industrialized world. Despite significant progress in early stage disease, survival rates for advanced disease remain low. Maintenance therapy is a treatment strategy that has been investigated extensively in NSCLC. Therapies that have been studied in this setting in randomized trials to date include chemotherapy and molecularly targeted agents. Following the development of multiple new agents that show activity in NSCLC and have a tolerable side-effect profile, there has been increasing interest in utilizing them to maintain response to initial therapy after treatment with platinum-based doublets. Two effective strategies have evolved: continuation and switch maintenance. Despite improvements in progression-fre

SUBMITTER: Gentzler RD 

PROVIDER: S-EPMC3866994 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature