Is there a correlation between anti-pig antibody levels in humans and geographic location during childhood?

ABSTRACT:

Background

An initial observation suggested high levels of anti-pig antibodies in healthy humans who had spent their childhood in the Middle East. We tested larger cohorts to determine whether anti-pig antibody levels correlated with the geographic location in which the subject spent his/her childhood, because this might have implications for clinical trials of xenotransplantation.

Methods

Anti-pig IgM and IgG levels (by flow cytometry using peripheral blood mononuclear cells from wild-type and α1,3-galactosyltransferase gene-knockout pigs) and anti-Gal IgM and IgG levels (by enzyme-linked immunosorbent assay) were measured in 75 volunteers. Comparisons of antibody levels were also made based on subject age, gender, ABO blood group, diet, and history of vaccination.

Resul

SUBMITTER: Kumar G 

PROVIDER: S-EPMC3867204 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature