Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis.

ABSTRACT:

Background

Hyponatremia is the most common electrolyte disorder in clinical practice, and evidence to date indicates that severe hyponatremia is associated with increased morbidity and mortality. The aim of our study was to perform a meta-analysis that included the published studies that compared mortality rates in subjects with or without hyponatremia of any degree.

Methods and findings

An extensive Medline, Embase and Cochrane search was performed to retrieve the studies published up to October 1st 2012, using the following words: "hyponatremia" and "mortality". Eighty-one studies satisfied inclusion criteria encompassing a total of 850222 patients, of whom 17.4% were hyponatremic. The identification of relevant abstracts, the selection of studies and the subsequent data e

SUBMITTER: Corona G 

PROVIDER: S-EPMC3867320 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature