The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature.

ABSTRACT:

Background

Pituitary adenomas (PAs) are commonly occurring neoplasms with diverse endocrine and neurological effects. Although somatic gene mutations are uncommon in sporadic PAs, recent studies lend support to epigenetic modification as a potential cause of tumorigenesis and tumor progression.

Methods

A systematic literature review of the PubMed and Google Scholar databases was conducted to identify abstracts (n=1,082) pertaining to key targets and mechanisms implicated in epigenetic dysregulation of PAs published between 1993-2013. Data regarding histopathological subtype, target genes, mode of epigenetic modification, and clinical correlation were recorded and analyzed.

Results

Of the 47 that studies met inclusion criteria and focused on epigenomic assessment of PA

SUBMITTER: Pease M 

PROVIDER: S-EPMC3867353 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature