Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) may affect the development of diseases. The -2518A/G polymorphism in the regulatory region of the monocyte chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with cancer risk. However, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimation of the relationship between the -2518A/G polymorphism and cancer risk.

Methodology/principal findings

We performed a meta-analysis, including 4,162 cases and 5,173 controls, to evaluate the strength of the association between the -2518A/G polymorphism and cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Overall, the results indic

SUBMITTER: Da LS 

PROVIDER: S-EPMC3867394 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature