Abnormal white matter correlates with neuropsychological impairment in children with localization-related epilepsy.

ABSTRACT:

Purpose

The white matter (WM) is considered critical for linking cortical processing networks necessary for cognition. The aim of this study was to assess diffusion tensor imaging (DTI) measures of regional WM in children with nonlesional localization-related epilepsy in comparison to controls, and to determine the relation between lobar WM and neuropsychological performance.

Methods

Forty children with nonlesional localization-related epilepsy and 25 healthy controls with no neurological or psychiatric disorders and normal magnetic resonance imaging (MRI) were recruited. All patients and controls underwent neuropsychological testing that evaluated intelligence, language, memory, executive function, and motor function, as well as DTI to assess regional WM measures of fractio

SUBMITTER: Widjaja E 

PROVIDER: S-EPMC3867411 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature