Molecular epidemiology of Mycobacterium tuberculosis complex in Singapore, 2006-2012.

ABSTRACT:

Background

Tuberculosis remains common in Singapore, increasing in incidence since 2008. We attempted to determine the molecular epidemiology of Mycobacterium tuberculosis complex (MTC) isolates locally, identifying major circulating genotypes and obtaining a glimpse of transmission dynamics.

Methodology

Non-duplicate MTC isolates archived between 2006 and 2012 at the larger clinical tuberculosis laboratory in Singapore were sampled for spoligotyping and MIRU-VNTR typing, with case data obtained from the Singapore Tuberculosis Elimination Program registry database. Isolates between 2008 and 2012 were selected because of either multidrug-resistance or potential epidemiological linkage, whereas earlier isolates were randomly selected. Separate analyses were performed for the e

SUBMITTER: Lim LK 

PROVIDER: S-EPMC3867517 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature