NBN Gene Polymorphisms and Cancer Susceptibility: A Systemic Review.

ABSTRACT: The relationship between DNA repair failure and cancer is well established as in the case of rare, high penetrant genes in high cancer risk families. Beside this, in the last two decades, several studies have investigated a possible association between low penetrant polymorphic variants in genes devoted to DNA repair pathways and risk for developing cancer. This relationship would be also supported by the observation that DNA repair processes may be modulated by sequence variants in DNA repair genes, leading to susceptibility to environmental carcinogens. In this framework, the aim of this review is to provide the reader with the state of the art on the association between common genetic variants and cancer risk, limiting the attention to single nucleotide polymorphisms (SNPs) of the NBN g

SUBMITTER: Berardinelli F 

PROVIDER: S-EPMC3867719 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature