Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.

ABSTRACT: Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.

SUBMITTER: Lin H 

PROVIDER: S-EPMC3867937 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature