Efficient computation of minimal perturbation sets in gene regulatory networks.

ABSTRACT: In the last few decades, technological and experimental advancements have enabled a more precise understanding of the mode of action of drugs with respect to human cell signaling pathways and have positively influenced the design of new drug compounds. However, as the design of compounds has become increasingly target-specific, the overall effects of a drug on adjacent cellular signaling pathways remain difficult to predict because of the complexity of the interactions involved. Off-target effects of drugs are known to influence their efficacy and safety. Similarly, drugs which are more target-specific also suffer from lack of efficacy because their scope might be too limited in the context of cellular signaling. Even in situations where the signaling pathways targeted by a drug are known,

SUBMITTER: Garg A 

PROVIDER: S-EPMC3867968 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature