The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: summary and future directions.

ABSTRACT: OBJECTIVE The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study continues to address knowledge gaps in our understanding of type 1 diabetes and the effects of intensive therapy on its long-term complications. RESEARCH DESIGN AND METHODS During the DCCT (1982-1993), a controlled clinical trial of 1,441 subjects with type 1 diabetes, and the EDIC (1994-present), an observational study of the DCCT cohort, core data collection has included medical history questionnaires, surveillance health exams, and frequent laboratory and other evaluations for microvascular and macrovascular disease. Numerous collaborations have expanded the outcome data with more detailed investigations of cardiovascular disease, cognitive function, neuropat

SUBMITTER: Gubitosi-Klug RA 

PROVIDER: S-EPMC3867991 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature