Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma.

ABSTRACT:

Background

Two recent genome-wide association studies (GWASs) identified five single nucleotide polymorphisms (SNPs; rs965513, rs944289, rs966423, rs2439302, and rs116909374) associated with papillary thyroid carcinoma (PTC). Each variant showed highly significant but moderate to low disease risk. Here we assessed the cumulative risk and predictive value of the five SNPs.

Methods

We genotyped two cohorts of individuals, 747 PTC cases and 1047 controls from Ohio and 1795 PTC cases and 2090 controls from Poland. Cumulative genetic risk scores were calculated using unweighted and weighted approaches.

Results

All five SNPs showed significant association with PTC. The average cumulative risk score in cases was significantly higher than in controls (p<2.2×10(-16)). Each add

SUBMITTER: Liyanarachchi S 

PROVIDER: S-EPMC3868253 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature