Enhanced autoimmunity associated with induction of tumor immunity in thyroiditis-susceptible mice.

ABSTRACT:

Background

Immunotherapeutic modalities to bolster tumor immunity by targeting specific sites of the immune network often result in immune dysregulation with adverse autoimmune sequelae. To understand the relative risk for opportunistic autoimmune disorders, we studied established breast cancer models in mice resistant to experimental autoimmune thyroiditis (EAT). EAT is a murine model of Hashimoto's thyroiditis, an autoimmune syndrome with established MHC class II control of susceptibility. The highly prevalent Hashimoto's thyroiditis is a prominent autoimmune sequela in immunotherapy, and its relative ease of diagnosis and treatment could serve as an early indicator of immune dysfunction. Here, we examined EAT-susceptible mice as a combined model for induction of tumor immunity a

SUBMITTER: Kari S 

PROVIDER: S-EPMC3868308 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature