Parameningeal rhabdomyosarcoma in pediatric age: results of a pooled analysis from North American and European cooperative groups.

ABSTRACT:

Background

Parameningeal (PM) site is a well-known adverse prognostic factor in children with localized rhabdomyosarcoma (RMS). To identify risk factors associated with outcome at this site, we pooled data from 1105 patients treated in 10 studies conducted by European and North American cooperative groups between 1984 and 2004.

Patients and methods

Clinical factors including age, histology, size, invasiveness, nodal involvement, Intergroup Rhabdomyosarcoma Study (IRS) clinical group, site, risk factors for meningeal involvement (MI), study group, and application of radiotherapy (RT) were studied for their impact on event-free and overall survival (EFS and OS).

Results

Ten-year EFS and OS were 62.6 and 66.1% for the whole group. Patients without initial RT showed worse

SUBMITTER: Merks JH 

PROVIDER: S-EPMC3868324 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature