Genetic links between post-reproductive lifespan and family size in Framingham.

ABSTRACT:

Background and objectives

Is there a trade-off between children ever born (CEB) and post-reproductive lifespan in humans? Here, we report a comprehensive analysis of reproductive trade-offs in the Framingham Heart Study (FHS) dataset using phenotypic and genotypic correlations and a genome-wide association study (GWAS) to look for single-nucleotide polymorphisms (SNPs) that are related to the association between CEB and lifespan.

Methodology

We calculated the phenotypic and genetic correlations of lifespan with CEB for men and women in the Framingham dataset, and then performed a GWAS to search for SNPs that might affect the relationship between post-reproductive lifespan and CEB.

Results

We found significant negative phenotypic correlations between CEB and lifespan i

SUBMITTER: Wang X 

PROVIDER: S-EPMC3868361 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature