Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis.

ABSTRACT:

Background

The gene ANK3 is implicated in bipolar disorder and schizophrenia. The present study investigated the influence of this gene on cognitive performance and brain structure among individuals with first-episode psychosis (FEP). The brief illness duration of an FEP sample makes it well suited for studying the effects of genetic variation.

Methods

We genotyped 2 single nucleotide polymorphisms (SNPs; rs1938526 and rs10994336) in ANK3 in patients with FEP. Multivariate analysis of variance compared risk allele carriers and noncarriers on 6 domains of cognition consistent with MATRICS consensus. A subsample of 82 patients was assessed using magnetic resonance imaging. We compared brain structure between carriers and noncarriers using cortical thickness analysis and voxel-

SUBMITTER: Cassidy C 

PROVIDER: S-EPMC3868663 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature