Efficient semiparametric estimation of short-term and long-term hazard ratios with right-censored data.

ABSTRACT: The proportional hazards assumption in the commonly used Cox model for censored failure time data is often violated in scientific studies. Yang and Prentice (2005) proposed a novel semiparametric two-sample model that includes the proportional hazards model and the proportional odds model as sub-models, and accommodates crossing survival curves. The model leaves the baseline hazard unspecified and the two model parameters can be interpreted as the short-term and long-term hazard ratios. Inference procedures were developed based on a pseudo score approach. Although extension to accommodate covariates was mentioned, no formal procedures have been provided or proved. Furthermore, the pseudo score approach may not be asymptotically efficient. We study the extension of the short-term and long-t

SUBMITTER: Diao G 

PROVIDER: S-EPMC3868993 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature