Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut.

ABSTRACT:

Background

Fecal bacteriotherapy ('stool transplant') can be effective in treating recurrent Clostridium difficile infection, but concerns of donor infection transmission and patient acceptance limit its use. Here we describe the use of a stool substitute preparation, made from purified intestinal bacterial cultures derived from a single healthy donor, to treat recurrent C. difficile infection that had failed repeated standard antibiotics. Thirty-three isolates were recovered from a healthy donor stool sample. Two patients who had failed at least three courses of metronidazole or vancomycin underwent colonoscopy and the mixture was infused throughout the right and mid colon. Pre-treatment and post-treatment stool samples were analyzed by 16 S rRNA gene sequencing using the Ion Torr

SUBMITTER: Petrof EO 

PROVIDER: S-EPMC3869191 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature