Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics.

ABSTRACT:

Rationale

Mitochondria, although required for cellular ATP production, are also known to have other important functions that may include modulating cellular responses to environmental stimuli. However, the mechanisms whereby mitochondria impact cellular phenotype are not yet clear.

Objective

To determine how mitochondria impact endothelial cell function.

Methods and results

We report here that stimuli for endothelial cell proliferation evoke strong upregulation of mitochondrial uncoupling protein 2 (UCP2). Analysis in silico indicated increased UCP2 expression is common in highly proliferative cell types, including cancer cells. Upregulation of UCP2 was critical for controlling mitochondrial membrane potential (Δψ) and superoxide production. In the absence of UCP2, en

SUBMITTER: Shimasaki Y 

PROVIDER: S-EPMC3869454 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature