Open-label milnacipran for patients with persistent knee pain 1 year or longer after total knee arthroplasty: a pilot study.

ABSTRACT: The current study investigates whether milnacipran is effective in reducing pain and improving function in patients with persistent pain ≥ 1 year after total knee arthroplasty. This was a 12-week open-label study of flexibly dosed milnacipran in patients (N = 5) experiencing chronic persistent knee pain ≥ 1 year following total knee arthroplasty in the absence of new injury, infection, or implant failure. Subjects were identified from October 2010 to August 2011 through the Duke University Medical Center orthopedic clinic (Durham, North Carolina), typically during 1-year postoperative follow-up visits, and were referred by their orthopedic surgeon. Milnacipran treatment was associated with reduction in pain according to the primary outcome measure of the visual analog scale (VAS) score for

SUBMITTER: Marks DM 

PROVIDER: S-EPMC3869602 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature