Vitamin D receptor, an important transcription factor associated with aldosterone-producing adenoma.

ABSTRACT:

Objective

To explore the endocrine mechanisms of aldosterone-producing adenoma (APA) by using the microarray expression profiles of normal and APA samples.

Methods

The gene expression profile GSE8514 was downloaded from Gene Expression Omnibus database, including samples from normal adrenals (n = 5) and APAs (n = 10). The differentially expressed genes (DEGs) were identified by samr package and endocrine DEGs were obtained according to Clinical Genome Database. Then, functional enrichment analysis of screened DEGs was performed by DAVID (Database for Annotation, Visualization and Integrated Discovery). Finally, a regulatory network was constructed to screen endocrine genes related with adrenal dysfunction and pathway enrichment analysis for the constructed network was perfor

SUBMITTER: Bi C 

PROVIDER: S-EPMC3869669 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature