A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.

ABSTRACT: Aging of biological systems is controlled by various processes which have a potential impact on gene expression. Here we report a genome-wide transcriptome analysis of the fungal aging model Podospora anserina. Total RNA of three individuals of defined age were pooled and analyzed by SuperSAGE (serial analysis of gene expression). A bioinformatics analysis identified different molecular pathways to be affected during aging. While the abundance of transcripts linked to ribosomes and to the proteasome quality control system were found to decrease during aging, those associated with autophagy increase, suggesting that autophagy may act as a compensatory quality control pathway. Transcript profiles associated with the energy metabolism including mitochondrial functions were identified to fluct

SUBMITTER: Philipp O 

PROVIDER: S-EPMC3869774 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature