Integrative network analysis unveils convergent molecular pathways in Parkinson's disease and diabetes.

ABSTRACT:

Background

Shared dysregulated pathways may contribute to Parkinson's disease and type 2 diabetes, chronic diseases that afflict millions of people worldwide. Despite the evidence provided by epidemiological and gene profiling studies, the molecular and functional networks implicated in both diseases, have not been fully explored. In this study, we used an integrated network approach to investigate the extent to which Parkinson's disease and type 2 diabetes are linked at the molecular level.

Methods and findings

Using a random walk algorithm within the human functional linkage network we identified a molecular cluster of 478 neighboring genes closely associated with confirmed Parkinson's disease and type 2 diabetes genes. Biological and functional analysis identified the pro

SUBMITTER: Santiago JA 

PROVIDER: S-EPMC3869818 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature