Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity.

ABSTRACT:

Unlabelled

Homologous recombination mediates error-free repair of DNA double-strand breaks (DSB). RAD51 is an essential protein for catalyzing homologous recombination and its recruitment to DSBs is mediated by many factors including RAD51, its paralogs, and breast/ovarian cancer susceptibility gene products BRCA1/2. Deregulation of these factors leads to impaired DNA repair, genomic instability, and cellular sensitivity to chemotherapeutics such as cisplatin and PARP inhibitors. microRNAs (miRNA) are short, noncoding RNAs that posttranscriptionally regulate gene expression; however, the contribution of miRNAs in the regulation of homologous recombination is not well understood. To address this, a library of human miRNA mimics was systematically screened to pinpoint several miRNAs

SUBMITTER: Huang JW 

PROVIDER: S-EPMC3869885 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature