The role of rs2237781 within GRM8 in eating behavior.

ABSTRACT:

Introduction

The glutamate receptor, metabotropic 8 gene (GRM8) encodes a G-protein-coupled glutamate receptor and has been associated with smoking behavior and liability to alcoholism implying a role in addiction vulnerability. Data from animal studies suggest that GRM8 may be involved in the regulation of the neuropeptide Y and melanocortin pathways and might influence food intake and metabolism. This study aimed to investigate the effects of the genetic variant rs2237781 within GRM8 on human eating behavior.

Methods

The initial analysis included 548 Sorbs from Germany who have been extensively phenotyped for metabolic traits and who completed the German version of the three-factor eating questionnaire. In addition, we analyzed two independent sample sets comprising 293 su

SUBMITTER: Gast MT 

PROVIDER: S-EPMC3869977 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature