The intestinal microbiota interferes with the microRNA response upon oral Listeria infection.

ABSTRACT:

Unlabelled

The intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining homeostasis. Listeria monocytogenes is the agent of listeriosis, an infection transmitted to humans upon ingestion of contaminated food. Crossing of the intestinal barrier is a critical step of the infection before dissemination into deeper organs. Here, we investigated the role of the intestinal microbiota in the regulation of host protein-coding genes and microRNA (miRNA or miR) expression during Listeria infection. We first established the intestinal miRNA signatures corresponding to the 10 most highly expressed miRNAs in the murine ileum of conventional and germf

SUBMITTER: Archambaud C 

PROVIDER: S-EPMC3870255 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature