Swimming upstream: identifying proteomic signals that drive transcriptional changes using the interactome and multiple "-omics" datasets.

ABSTRACT: Signaling and transcription are tightly integrated processes that underlie many cellular responses to the environment. A network of signaling events, often mediated by post-translational modification on proteins, can lead to long-term changes in cellular behavior by altering the activity of specific transcriptional regulators and consequently the expression level of their downstream targets. As many high-throughput, "-omics" methods are now available that can simultaneously measure changes in hundreds of proteins and thousands of transcripts, it should be possible to systematically reconstruct cellular responses to perturbations in order to discover previously unrecognized signaling pathways. This chapter describes a computational method for discovering such pathways that aims to compensat

SUBMITTER: Huang SS 

PROVIDER: S-EPMC3870464 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature