Zebrafish heart failure models for the evaluation of chemical probes and drugs.

ABSTRACT: Heart failure is a complex disease that involves genetic, environmental, and physiological factors. As a result, current medication and treatment for heart failure produces limited efficacy, and better medication is in demand. Although mammalian models exist, simple and low-cost models will be more beneficial for drug discovery and mechanistic studies of heart failure. We previously reported that aristolochic acid (AA) caused cardiac defects in zebrafish embryos that resemble heart failure. Here, we showed that cardiac troponin T and atrial natriuretic peptide were expressed at significantly higher levels in AA-treated embryos, presumably due to cardiac hypertrophy. In addition, several human heart failure drugs could moderately attenuate the AA-induced heart failure by 10%-40%, further ve

SUBMITTER: Huang CC 

PROVIDER: S-EPMC3870487 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature