H3F3A K27M mutations in thalamic gliomas from young adult patients.

ABSTRACT:

Introduction

Mutations in H3F3A, which encodes histone H3.3, commonly occur in pediatric glioblastoma. Additionally, H3F3A K27M substitutions occur in gliomas that arise at midline locations (eg, pons, thalamus, spine); moreover, this substitution occurs mainly in tumors in children and adolescents. Here, we sought to determine the association between H3F3A mutations and adult thalamic glioma.

Methods

Genomic H3F3A was sequenced from 20 separate thalamic gliomas. Additionally, for 14 of the 20 gliomas, 639 genes--including cancer-related genes and chromatin-modifier genes--were sequenced, and the Infinium HumanMethylation450K BeadChip was used to examine DNA methylation across the genome.

Results

Of the 20 tumors, 18 were high-grade thalamic gliomas, and of these 18,

SUBMITTER: Aihara K 

PROVIDER: S-EPMC3870821 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature