Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infection.

ABSTRACT:

Background

Infectious bronchitis virus (IBV), a prototype of the Coronaviridae family, is an economically important causative agent of infectious bronchitis in chickens and causes an acute and highly contagious upper respiratory tract infections that may lead to nephritis. However, the molecular antiviral mechanisms of chickens to IBV infection remain poorly understood. In this study, we conducted global gene expression profiling of chicken kidney tissue after nephropathogenic IBV infection to better understand the interactions between host and virus.

Results

IBV infection contributed to differential expression of 1777 genes, of which 876 were up-regulated and 901 down-regulated in the kidney compared to those of control chickens and 103 associated with immune and inflammato

SUBMITTER: Cong F 

PROVIDER: S-EPMC3870970 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature