Archetypal analysis of diverse Pseudomonas aeruginosa transcriptomes reveals adaptation in cystic fibrosis airways.

ABSTRACT:

Background

Analysis of global gene expression by DNA microarrays is widely used in experimental molecular biology. However, the complexity of such high-dimensional data sets makes it difficult to fully understand the underlying biological features present in the data.The aim of this study is to introduce a method for DNA microarray analysis that provides an intuitive interpretation of data through dimension reduction and pattern recognition. We present the first "Archetypal Analysis" of global gene expression. The analysis is based on microarray data from five integrated studies of Pseudomonas aeruginosa isolated from the airways of cystic fibrosis patients.

Results

Our analysis clustered samples into distinct groups with comprehensible characteristics since the archetypes r

SUBMITTER: Thogersen JC 

PROVIDER: S-EPMC3870984 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature