Comparative toxicogenomic responses of mercuric and methyl-mercury.

ABSTRACT:

Background

Mercury is a ubiquitous environmental toxicant that exists in multiple chemical forms. A paucity of information exists regarding the differences or similarities by which different mercurials act at the molecular level.

Results

Transcriptomes of mixed-stage C. elegans following equitoxic sub-, low- and high-toxicity exposures to inorganic mercuric chloride (HgCl2) and organic methylmercury chloride (MeHgCl) were analyzed. In C. elegans, the mercurials had highly different effects on transcription, with MeHgCl affecting the expression of significantly more genes than HgCl2. Bioinformatics analysis indicated that inorganic and organic mercurials affected different biological processes. RNAi identified 18 genes that were important in C. elegans response to mercurial e

SUBMITTER: McElwee MK 

PROVIDER: S-EPMC3870996 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature