RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation.

ABSTRACT:

Background

The production of enzymes by an industrial strain requires a complex adaption of the bacterial metabolism to the conditions within the fermenter. Regulatory events within the process result in a dynamic change of the transcriptional activity of the genome. This complex network of genes is orchestrated by proteins as well as regulatory RNA elements. Here we present an RNA-Seq based study considering selected phases of an industry-oriented fermentation of Bacillus licheniformis.

Results

A detailed analysis of 20 strand-specific RNA-Seq datasets revealed a multitude of transcriptionally active genomic regions. 3314 RNA features encoded by such active loci have been identified and sorted into ten functional classes. The identified sequences include the expected RNA fe

SUBMITTER: Wiegand S 

PROVIDER: S-EPMC3871023 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature