C-kit expression profile and regulatory factors during spermatogonial stem cell differentiation.

ABSTRACT:

Background

It has been proven that c-kit is crucial for proliferation, migration, survival and maturation of spermatogenic cells. A periodic expression of c-kit is observed from primordial germ cells (PGCs) to spermatogenetic stem cells (SSCs), However, the expression profile of c-kit during the entire spermatogenesis process is still unclear. This study aims to reveal and compare c-kit expression profiles in the SSCs before and after the anticipated differentiation, as well as to examine its relationship with retinoic acid (RA) stimulation.

Results

We have found that there are more than 4 transcripts of c-kit expressed in the cell lines and in the testes. The transcripts can be divided into short and long categories. The long transcripts include the full-length canonical c-

SUBMITTER: Zhang L 

PROVIDER: S-EPMC3871025 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature