Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.

ABSTRACT: Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries.

SUBMITTER: Jayanth TT 

PROVIDER: S-EPMC3871195 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature