Sprouty-2 regulates HIV-specific T cell polyfunctionality.

ABSTRACT: The ability of individual T cells to perform multiple effector functions is crucial for protective immunity against viruses and cancer. This polyfunctionality is frequently lost during chronic infections; however, the molecular mechanisms driving T cell polyfunctionality are poorly understood. We found that human T cells stimulated by a high concentration of antigen lacked polyfunctionality and expressed a transcription profile similar to that of exhausted T cells. One specific pathway implicated by the transcription profile in control of T cell polyfunctionality was the MAPK/ERK pathway. This pathway was altered in response to different antigen concentrations, and polyfunctionality correlated with upregulation of phosphorylated ERK. T cells that were stimulated with a high concentration o

SUBMITTER: Chiu YL 

PROVIDER: S-EPMC3871241 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature